DOI: 10.1039/A701948C
(Paper)
Reference Section for: J. Chem. Soc., Perkin Trans. 1, 1997, 2329-2336
The synthesis of antioxidants showing selective affinity for low density lipoproteins
(Note: The full text of this document is currently only available in the PDF Version )
David W. Brown, Mary F. Mahon, Aleyamma Ninan and Malcolm Sainsbury
Abstract
The syntheses of some novel indolinosteroids, indolinodecalins and spiro tetrahydroquinolinopiperidines are described. These compounds act as chain-breaking antioxidants and in some cases show very selective binding to LDL particles in human plasma. Aspects of the stereoselectivity in the Fischer indolisation of three common steroidal ketones and the reduction of the resultant indoles to indolines are considered.
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