Synthesis of indoles and quinolones by sequential Wittig and Heck reactions

Abstract

Trifluoroacetamido derivatives 18a–c and 19a–c react with phosphorane 2 in boiling toluene to give the corresponding enamines 12a–c and 13a–c respectively which are precursors of the trifluoromethylated indoles 14a–c and quinolones 15a–c.

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