Takefumi Momose, Naoki Toyooka and Makoto Jin
Enantiodivergent synthesis of the enantio-pure cis,cis 3-protected 2,6-disubstituted piperidin-3-ol 1 has been achieved via a biochemical method, and the absolute stereochemistry of (+)-1 has been established by its conversion into the known piperidine (-)-17. The utility of 1 as a chiral building block for alkaloid synthesis is demonstrated by the total synthesis of (-)-cassine and (+)-spectaline.