Synthesis of the aromatic unit of calicheamicin γ₁^I

Abstract

Vanillin and piperonal are each converted into methyl 2,3-dimethoxy-6-methyl-4-(prop-2-enyl)benzoate 12, and this is then elaborated into methyl 4-hydroxy-3-iodo-5,6-dimethoxy-2-methylbenzoate 24, which represents the aromatic unit of calicheamicin γ₁^I.

References

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