DOI: 10.1039/A605572I
(Paper)
J. Chem. Soc., Perkin Trans. 1, 1997, 3479-3484
The X-ray crystal structure, conformation and preparation of anti-3,3,6,6-tetramethylthiepane-4,5-diol: stereochemistry of reduction of a heterocyclic α-hydroxy ketone
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Neil Feeder, Michael J. Ginnelly, Ray V. H. Jones, Susan OSullivan, Stuart Warren and Paul Wyatt
Abstract
The X-ray crystal structure and conformation of the anti title diol is described together with stereoselective syntheses of syn- and anti-diols from a readily available acyloin. Some control of the stereoselective reduction of α-hydroxy ketones by chelating and non-chelating reducing agents is possible.