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DOI: 10.1039/A604879J (Paper) Reference Section for: J. Chem. Soc., Perkin Trans. 1, 1997, 1069-1072

Derivatives of L-pyrimidylalanine

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Gury Zvilichovsky and Vadim Gurvich

Abstract

Optically active derivatives of L-isoxazolo[2,3-a ]pyrimidin-4-ylalanine are prepared by the combination of Birch reduction of the phenyl ring of L-phenylalanine, followed by ozonolysis and condensation with 3-amino-5-oxo-4-phenyl-2,5-dihydroisoxazole. Ring cleavage of the five-membered ring by reduction, oxidation and nucleophiles gives pyrimidylalanine derivatives.

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