A procedure for the preparation of cardioactive steroid precursors: synthesis of 3β-acetoxy-21-hydroxy-5α-pregn-14-en-20-one

Abstract

The efficient preparation of an important precursor in the synthesis of cardioactive steroids is reported. The key step, the introduction of a 21-hydroxy group into a 14,15-dehydropregnane derivative, is accomplished by reaction of the enol ether with dimethyldioxirane.

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