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DOI: 10.1039/A603699F (Paper) Reference Section for: J. Chem. Soc., Perkin Trans. 1, 1997, 547-554

Dipeptides bearing nucleobases for the synthesis of novel peptide nucleic acids

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Gordon Lowe and Tirayut Vilaivan

Abstract

Three stereoisomers (cis-L, trans-D and cis-D) of N-Fmoc-glycyl-4-(thymin-1-yl)proline and their pentafluorophenyl esters have been prepared for use in the synthesis of novel peptide nucleic acids. In addition, N-Fmoc-glycyl-4-(N[hair space]6-benzoyladenin- 9-yl)proline, N-Fmoc-glycyl-4-(N[hair space]4-benzoylcytosin -1-yl)proline and N-Fmoc-glycyl-4-(N[hair space]2-isobutyrylguan in-9-yl)proline and their pentafluorophenyl esters of the cis-D series have been synthesized.

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