The First Preparation of 6β-Bromo Codeine and Morphine Derivatives. Kinetic vs. Thermodynamic Control

(Note: The full text of this document is currently only available in the PDF Version )

Csaba Simon, Sándor Hosztafi and Sándor Makleit


Abstract

Starting from the hydrogen halide salts of morphine and codeine derivatives, 6α-halogeno(Cl, Br)-substituted codeine and morphine derivatives have been prepared under Mitsunobu conditions.


References

  1. Cs. Simon, S. Hosztafi and S. Makleit, Tetrahedron Lett., 1993, 34, 6475 Search PubMed.
  2. O. Mitsunobu, Synthesis, 1981, 1 Search PubMed.
  3. B. R. Castro, Org. React., 1983, 29, 1 Search PubMed.
  4. D. L. Hughes, Org. React., 1992, 42, 335 Search PubMed.
  5. D. L. Hughes, Org. Prep. Proced. Int., 1996, 28, 127 Search PubMed.
  6. G. Stork and F. H. Clarke, J. Am. Chem. Soc., 1956, 78, 4619 Search PubMed.
Click here to see how this site uses Cookies. View our privacy policy here.