Reactions with 3-Amino-5-trifluoromethyl-1,2,4-triazole: a Simple Route to Fluorinated Poly-substituted Triazolo[1,5-a]pyrimidine and Triazolo[5,1-c]triazine Derivatives

Abstract

3-Amino-5-trifluoromethyl-1,2,4-triazole has been utilized for the syntheses of poly-substituted 2-trifluoromethyl-[1,2,4]triazolo[1,5-a] pyrimidine derivatives, via its reactions with acrylonitrile derivatives and various 1,3-dicarbonyl compounds, and of trifluoromethyl[1,2,4]triazolo[5,1-c]triazine derivatives, via its diazotization and coupling with active methylene reagents.

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