Rapid Synthesis of (±)-(E)- and (±)-(Z)-1-Amino-1-aminomethyl-2-(hydroxymethyl)cy clopropanes, Preparation of their Dichloroplatinum(II) Complexes, and Crystal Structure of a Derivative of the (±)-(E) Isomer

Abstract

An efficient four-step synthesis of racemic Z and E forms of 1-amino-1-aminomethyl-2-(hydroxymethyl)cyclopropane is described, along with the preparation and cell-growth inhibition evaluation of the corresponding dichloroplatinum(II) complexes; the crystal structure of the synthetic intermediate (E)-1-[(benzyloxycarbonyl)aminomethyl]-1-dibenzylamino-2 -(hydroxymethyl)cyclopropane has been determined.

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