Studies on the Synthesis and Cyclization Reactions of2-(5-Amino-3-arylpyrazol-1-yl)-3-methylquinoxalines

(Note: The full text of this document is currently only available in the PDF Version )

Hassan A. El-Sherief, Abdalla M. Mahmoud and Ahmed A. Ismaiel


Abstract

A series of2-(5-amino-3-arylpyrazol-1-yl)-3-methylquinoxalines (2a–d)has been synthesized by the condensation of2-hydrazino-3-methylquinoxaline (1) with substitutedbenzoylacetonitriles and converted into the corresponding3,4-diaryl-1-(3-methylquinoxalin-2-yl)-4,8-dihydro-1H -pyrazolo[3,4-e ][1,4]thiazepin-7(6H )-ones(7a–d) and2-(3-aryl-4,5,6,7-tetrahydro-5-alkyl/aryl-1H -pyrazolo[3,4-d ]pyrimidin-1-yl)-3-methylquinoxalines(8a–e).


References

  1. Y. Kurasawa and A. Takad, Heterocycles, 1986, 24, 2321 CAS.
  2. Y. Kurasawa, M. Muramatsu, K. Yamazaki, S. Tajima, Y. Okamoto and A. Takada, J. Heterocycl. Chem., 1986, 23, 1379, 1391.
  3. G. Skata, K. Makino and Y. Kurasawa, Heterocycles, 1988, 27, 2481.
  4. G. Vertuani, P. Giori, M. Guarneri and G. P. Sarto, J. Pharm. Sci., 1985, 74, 1013 CAS.
  5. P. Giori, T. Poli, C. B. Vicentini, M. Manfrini, M. Guarneri and V. Brandolini, Farmaco, Ed. Sci., 1985, 40, 795 Search PubMed.
  6. C. B. Vincentini, T. Poli, M. Manfrini, M. Guarnerim, P. Giori and V. Brandolini, Farmaco, Ed. Sci., 1987, 42, 133 Search PubMed.
  7. C. B. Vicentini, T. Poli, A. C. Veronese, V. Brandolini, M. Manfrini, M. Guarneri and P. Giori, Pestic. Sci., 1989, 27, 77 Search PubMed.
  8. C. B. Vicentini, A. C. Veronese, P. Giori, B. Lumachi and M. Guarneri, Tetrahedron, 1990, 46, 5777 CrossRef CAS.
  9. G. Szilagyi and P. Dvortsak, Monatsh. Chem., 1989, 120, 131 CAS.
  10. L. Jennig, J. Hofmann, M. Alva-Astudillo and G. Mann, J. Prakt. Chem., 1990, 332(1), 351 CrossRef CAS.
  11. M. Tramontini and L. Angiolini, Tetrahedron, 1990, 46, 1791 CrossRef CAS.
Click here to see how this site uses Cookies. View our privacy policy here.