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DOI: 10.1039/A704743F (Paper) Reference Section for: J. Chem. Soc., Dalton Trans., 1997, 4113-4118

Oxidative damage on RNA mediated by cationic metalloporphyrin–antisense oligonucleotides conjugates[hair space]†

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Victor Duarte, Sophie Sixou, Gilles Favre, Geneviève Pratviel and Bernard Meunier

Abstract

A manganese cationic porphyrin covalently linked to the 5′ end of an antisense oligonucleotide was shown to mediate sequence-specific oxidative lesions on a mRNA target when activated by KHSO5. This manganese porphyrin cleaver did not induce direct RNA strand breaks but promoted the arrest of reverse transcription due to oxidative damage on bases of the RNA template.

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