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DOI: 10.1039/A703600K (Paper) Reference Section for: J. Chem. Soc., Dalton Trans., 1997, 3979-3980

Intramolecular migration of co-ordinated platinum from a sulfur to N7 in the nucleopeptide Met-d(TpG) (5′-O-methioninate-N-ylcarbonylthymidine 2′-deoxyguanosine monophosphate)[hair space]†

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Jan-Maarten Teuben, Stella S. G. E. van Boom and Jan Reedijk

Abstract

The nucleopeptide Met-d(TpG) (5′-O-methioninate-N-ylcarbonylthymidine 2′-deoxyguanosine monophosphate), containing a methionine moiety covalently linked to a TpG dinucleotide, upon reaction with platinum complexes, initially yielded platinum co-ordination to the sulfur atom, which subsequently is substituted by the N7 atom of guanine for the reaction with monofunctional [Pt(dien)Cl]Cl (dien = diethylenetriamine); in the case of the cisplatin analogue [Pt(en)Cl2] (en = ethane-1,2-diamine) formation of a stable S,N chelate takes place.

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