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DOI: 10.1039/A702757E (Paper) Reference Section for: J. Chem. Soc., Dalton Trans., 1997, 3435-3443

Synthesis of gold(I), silver(I) and copper(I) complexes containing substituted (2-aminophenyl)phosphines. Molecular structures of [AuI(2-H2NC6H4PPh2)], [AuI{(±)-2-H2NC6H4PMePh}] and (±)-[Cu(2-H2NC6H4PPh2)2];PF6

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Peter Papathanasiou, Geoffrey Salem, Paul Waring and Anthony C. Willis

Abstract

Linear gold(I) complexes of type [AuI(L)] and [AuL2]I (L = 2-H2NC6H4PPhR, R = Me or Ph) have been prepared by the reaction of the appropriate ligand with [NBun4][AuI2] in ethanol. The neutral ligand L is co-ordinated to the metal centre via the phosphorus donor atom. The structures of the complexes [AuI(2-H2NC6H4PPh2)] and [AuI{(±)-2-H2NC6H4PMePh}] have been confirmed by X-ray analyses with the latter, but not the former, complex exhibiting auriophilicity. Metathesis of these compounds with NH4PF6 gave the corresponding hexafluorophosphate salts [AuLn]PF6 (n = 1 or 2). Tetrahedral complexes of the type [MLn]PF6 (L = 2-H2NC6H4PPhR; R = Ph, M = Ag or Cu, n = 2 or 3; R = Me, M = Cu, n = 2 or 3; R = Me, M = Ag, n = 3) have also been prepared via reaction of the appropriate ligand with [Cu(NCMe)4]PF6 in acetonitrile or AgNO3 in ethanol followed by metathesis with NH4PF6. The molecular structure of (±)-[Cu(2-H2NC6H4PPh2)2]PF6 has been confirmed by X-ray crystallography. All of the complexes have been shown by NMR spectroscopy to undergo facile ligand-exchange reactions in solution. These complexes are seen as potential anticancer agents. Preliminary biological studies have shown them to be active against three mouse tumour cell lines in vitro with cytotoxicities of certain of these complexes being comparable to that of cis-diamminedichloroplatinum(II), cisplatin, and bis[1,2-bis(diphenylphosphino)ethane]gold(I) iodide.

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