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DOI: 10.1039/A702676E (Paper) Reference Section for: J. Chem. Soc., Dalton Trans., 1997, 2387-2390

Metal ion and proton stabilisation of turn motif in the synthetic octapeptide histidyltris(glycylhistidyl)glycine

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Raffaele P. Bonomo, Luigi Casella, Luca De Gioia, Henriette Molinari, Giuseppe Impellizzeri, Trace Jordan, Giuseppe Pappalardo, Roberto Purrello and Enrico Rizzarelli

Abstract

Protonation and metal ion co-ordination can induce α- and γ-turns respectively, of the linear octapeptide His-(Gly-His)3-Gly (His = histidine, Gly = glycine) and in both cases the imidazole groups of appropriately positioned His residues have been shown to be essential in the stabilisation of the folded structure; divalent metal ions exhibit different folding inducing ability of the octapeptide with Ni2+ having the greatest ability at physiological pH.

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