Regioselective addition of an alkyne to both CO and CNPr functionalities in osmium clusters

Abstract

Reaction of [Os₃(CO)₁₀(CNPr)(NCMe)] with methyl propiolate at 0 °C gave [Os₂(CO)₆{µ-η²:η ³-C(OH)C(CO₂Me)=CHCNHPr}] as the major product and [Os₂(CO)₆{µ-η²:η ³-C(OH)CH=C(CO₂Me)CNHPr}] as the minor product, in which two kinds of C–C bond formations occur regioselectively involving coupling of alkyne and CO as well as coupling of alkyne and CNPr; the stereochemistry is likely to be mediated by the co-ordinated isocyanide.

References

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