5-endo-trig Cyclisations in heterocycle synthesis: enantiospecific synthesis of (+)-monomorine I

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Malcolm B. Berry, Gareth J. Rowlands, Donald Craig and Philip S. Jones


Abstract

The indolizidine alkaloid monomorine I is synthesised from D-norleucinol using 5-endo-trig cyclisation and intramolecular reductive amination as the key ring-forming steps.


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