Structure of a novel antimalarial gallium(III) complex with selective activity against chloroquine-resistant Plasmodium falciparum†

Abstract

The crystal structure of an amine phenol complex of gallium(III), [{1,12-bis(2-hydroxy-3-methoxybenzyl)-1,5,8,12-tetraazadodecane}gallium(III)] [Ga(madd)]⁺, a potent new antimalarial which selectively targets chloroquine-resistant organisms is reported; the compound is shown to directly inhibit heme polymerization.

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