Tandem annulations: a one operation construction of bicyclo[3.3.0]octan-1-ol and bicyclo[3.2.1]octan-1-ol skeletons by a three-component coupling reaction of alk-4-enyl iodides with CO and alkenes in the presence of zinc

Abstract

Under a one-electron reduction system composed of zinc and an aprotic solvent, alk-4-enyl iodides react with CO and alkenes to give bicyclo[3.3.0]octan-1-ols and bicyclo[3.2.1]octan-1-ols via radical/anionic dual annulations.

References

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