Antibody-catalysed glycosyl transfer reactions from in vitro immunization

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Jaehoon Yu, So Young Choi, Sungsoo Lee, Hansuh Mun, Hokoon Park, Hyun Joo Yoon, Sunjoo Jeong and Peter G. Schultz


Abstract

In vitro immunization using a 5-membered ring iminocyclitol afforded antibodies that catalyse the hydrolysis of p-nitrophenyl glucopyranoside and p-nitrophenyl galactopyranoside with rate enhancements (kcat/kuncat) of greater than 104.


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