A study of asymmetric protonation with chiral β-hydroxy sulfoxides. Asymmetric synthesis of (–)-epibatidine

Abstract

The asymmetric synthesis of (–)-epibatidine 1, employing as the key step the asymmetric protonation of the achiral lithum enolate of cyclohexanone derivative 5 with chiral β-hydroxy sulfoxide 3b, is described.

References

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