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DOI: 10.1039/A704376G (Paper) Reference Section for: Chem. Commun., 1997, 1643-1644

Synthesis and conformation of 3′-O,4′-C-methyleneribonucleosides, novel bicyclic nucleoside analogues for 2′,5′-linked oligonucleotide modification

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Satoshi Obika, Ken-ichiro Morio, Daishu Nanbu and Takeshi Imanishi

Abstract

Novel bicyclic nucleoside analogues 3′-O,4′-C-methyleneribonucleosides 1 are conveniently prepared starting from uridine; the sugar puckering of 1 is found to be nearly in the S-conformation by means of PM3 calculations and 1H NMR studies.

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