First total synthesis of (±)-hyperolactone A

Abstract

The first total synthesis of (±)-hyperolactone A, isolated from Hypericum chinense L., is accomplished from 3-furoic acid and 2-methylbutanal.

References

1. (a) M. Tada, M. Nagai, C. Okumura, Y. Osano and T. Matsuzaki, Chem. Lett., 1989, 683; (b) Y. Aramaki, K. Chiba and M. Tada, Phytochemistry, 1995, 38, 1419.
2. T. Kinoshita, D. Ichinari and J. Sinya, J. Heterocycl. Chem., 1996, 33, 1313.
3. E. Vedejs and S. Larsen, Org. Synth., 1990, Coll. Vol. VII, 277.
4. F. A. Davis and O. D. Stringer, J. Org. Chem., 1982, 47, 1774; F. A. Davis, L. C. Vishwakarma, J. M. Billmers and J. Finn, J. Org. Chem., 1984, 49, 3241.