The azomethine ylide strategy for β-lactam synthesis: the structure of the key 1,3-dipolar intermediate

Abstract

The thermolysis of the β-lactam-based oxazolidinone 1 leads to the formation of cycloadducts 2 and evidence is presented for the participation of the carboxylated azomethine ylide 4, rather than 3 (the more conventional product of oxazolidinone fragmentation), as the key 1,3-dipolar intermediate in this process.

References

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