Δ-cis-α-[Ru(RR-picchxnMe2 )(phen)]2+ shows minor groove AT selectivity with oligonucleotides

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Emma M. Proudfoot, Joel P. Mackay, Robert S. Vagg, Kymberley A. Vickery, Peter A. Williams and Peter Karuso


Abstract

NMR studies show that the ternary octahedral Δ-cis-α- [Ru(RR-picchxnMe2)(phen)]2+ cation binds with AT selectivity in the minor groove of [d(CGCGATCGCG)2] and [d(ATATCGATAT)2] duplexes through a non-intercalative interaction.


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