A pH cleavable linker for zone diffusion assays and single bead solution screens in combinatorial chemistry

(Note: The full text of this document is currently only available in the PDF Version )

Butrus Atrash and Mark Bradley


Abstract

A safety catch linker has been developed that allows efficient compound release into buffered aqueous solutions and agarose gels.


References

  1. M. A. Gallop, R. W. Barrett, W. J. Dower, S. P. A. Fodor and E. M. Gordon, J. Med. Chem., 1994, 37, 1233 CrossRef CAS; N. K. Terrett, M. Gardner, D. W. Gordon, R. J. Kobylecki and J. Steele, Tetrahedron, 1995, 51, 8135 CrossRef CAS; M. Rinnova and M. Lebl, Collect. Czech. Chem. Commun., 1996, 61, 171 CrossRef CAS.
  2. J. J. Burbaum, M. H. Ohlmeyer, J. C. Reader, I. Henderson, L. W. Dillard, G. Li Troy, T. L. Randle, N. H. Sigal, D. Chelsky and J. J. Baldwin, Proc. Natl. Acad. Sci. USA, 1995, 91, 6027; J. J. Baldwin, J. J. Burbaum, I. Henderson and M. H. Ohlmeyer, J. Am. Chem. Soc., 1995, 117, 5588 CrossRef CAS; C. P. Holmes and D. G. Jones, J. Org. Chem., 1995, 60, 2318 CrossRef CAS.
  3. S. Hoffmann and R. Frank, Tetrahedron Lett., 1994, 35, 7763 CrossRef CAS.
  4. M. Lebl, M. Patek, P. Kocis, V. Krchnak, V. J. Hruby, S. E. Salmon and K. S. Lam, Int. J. Pept. Protein Res., 1993, 41, 201 Search PubMed; S. E. Salmon, K. S. Lam, M. Lebl, A. Kandola, P. S. Khattri, S. Wade, M. Patek, P. Kocis, V. Krchnak, D. Thorpe and S. Felder, Proc. Natl. Acad. Sci. USA, 1993, 90, 11 708 CAS; P. Kocis, V. Krchnak and M. Lebl, Tetrahedron Lett., 1993, 34, 7251 CrossRef CAS.
  5. R. M. Cook, J. H. Adams and D. Hudson, Tetrahedron Lett., 1994, 35, 6777 CrossRef CAS.
  6. N. Bouloc, M. Phil Thesis, Diffusion Zone Assays for Bio-Active libraries—Light Mediated Compound Release, University of Southampton, 1996 Search PubMed.
Click here to see how this site uses Cookies. View our privacy policy here.