Synthesis of manoalide using a 1,2-metallate rearrangement

Abstract

Manoalide, a marine antiinflammatory sesterterpenoid, has been synthesised using a 1,2-metallate rearrangement of a higher order cuprate and a Pd⁰-catalysed carbonylation of an iodo alkene to generate the central dihydropyranone ring.

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