Dan J. Mitchell, David L. Jakeman, Tatyana I. Igumenova, Wendy A. Shuttleworth, Keith D. Miller and Jeremy N. S. Evans
Time-resolved solid-state rotational echo double resonance-edited NMR has been used to detect transient enzyme–intermediates containing two dipolar coupled spins that are unique to the intermediate, so that even resonances buried in the natural abundance background can be detected.