Immobilization and cleavage of DNA at cationic, self-assembled monolayers containing C₆₀ on gold

Abstract

A cationic, self-assembled monolayer on gold substrate can immobilize DNA without impairing its native structure; the site-specific photocleavage of the DNA is achieved by incorporation of [60]fullerene into the monolayer.

References

1. A. L. Weisenhorn, M. Egger, F. Ohnesorge, S. A. C. Gould, S.-P. Heyn, H. G. Hansma, R. L. Sinsheimer, H. E. Gaub and P. K. Hansma, Langmuir, 1991, 7, 8.
2. E.g.: H. Su, M. R. Kallury, M. Thompson and A. Roach, Anal. Chem., 1994, 66, 769 and references cited therein.
3. X.-H. Xu, H. C. Yang, T. E. Mallouk and A. J. Bard, J. Am. Chem. Soc., 1994, 116, 8386.
4. N. Higashi, T. Mori and M. Niwa, J. Chem. Soc., Chem. Commun., 1990, 225.
5. M. Niwa, T. Mori, E. Nishio, H. Nishimura and N. Higashi, J. Chem. Soc., Chem. Commun., 1992, 547.
6. M. Niwa, T. Mori and N. Higashi, J. Mater. Chem., 1992, 2, 245.
7. H. Tokuyama, S. Yamaga, E. Nakamura, T. Shiraki and Y. Sugiyama, J. Am. Chem. Soc., 1993, 115, 7918.
8. E. Tuite and B. Norden, J. Am. Chem. Soc., 1994, 116, 7548.
9. H. Porumb, Prog. Biophys. Mol. Biol., 1978, 34, 175.
10. W. B. Caldwell, K. Chen, C. A. Mirkin and S. J. Babinec, Langmuir, 1993, 9, 1945.
11. J. Piett and P. D. Moore, Photochem. Photobiol., 1982, 35, 705.
12. J. Marmur and P. Doty, J. Mol. Biol., 1962, 5, 109.