A novel class of conformationally restricted oligonucleotide
analogues: synthesis of 2′,3′-bridged monomers and
RNA-selective hybridisation
(Note: The full text of this document is currently only available in the PDF Version )
Poul Nielsen, Henrik M. Pfundheller and Jesper Wengel
Abstract
A novel 2′,3′-bicyclic nucleoside 5 has been synthesised
and incorporated into oligonucleotide analogues resulting in strong and
selective binding to an RNA complement.
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