View PDF Version
 
DOI: 10.1039/A608106A (Paper) Reference Section for: Chem. Commun., 1997, 385-386

Unique binding site for bis-benzimidazoles on transfer RNA

(Note: The full text of this document is currently only available in the PDF Version )

S. E. Sadat Ebrahimi, Amanda N. Wilton and Kenneth T. Douglas

Abstract

Ligands based on bis-benzimidazole structures related to Hoechst 33258 bind to transfer RNA with 1:1 stoichiometry and dissociation constants in the micromolar range, their interaction appearing significantly different in nature from that with duplex DNA, based on the ribonucleic acid-induced quenching of their fluorescence.

References

  1. F. A. Tanious, J. M. Veal, H. Buczak, L. S. Ratmeyer and W. D. Wilson, Biochemistry, 1992, 31, 3103 CrossRef CAS.
  2. M. J. Gait and J. Karn, Trends Biotechnol., 1995, 13, 430 CrossRef CAS.
  3. Y. Wang and R. R. Rando, Chem. Biol., 1995, 2, 281 CrossRef CAS.
  4. C. Zimmer, K. E. Reinert, G. Luck, U. Wahnert, G. Lober and H. Thrum, J. Mol. Biol., 1971, 58, 329 CrossRef CAS.
  5. D. S. Pilch, M. A. Kirolos, X. Liu, E. Plum and K. J. Breslauer, Biochemistry, 1995, 34, 9962 CrossRef CAS.
  6. W. D. Wilson, L. Ratmeyer, M. Zhao, L. Srekowski and D. Boykin, Biochemistry, 1993, 32, 4098 CrossRef CAS.
  7. J. Rubin and M. Sundaralingam, J. Biomol. Struct. Dyn., 1984, 2, 165 Search PubMed.
  8. W. J. Birdsall, Anderson, Jr. and N. Foster, Biochim. Biophys. Acta, 1989, 1007, 176 CAS.
  9. S. S. Ebrahimi, K. J. Embrey, K. T. Douglas, J. P. Parkinson, F. G. Loontiens and R. M. Clegg, J. Biomol. Struct. Dyn., 1995, 12, a202 Search PubMed.
  10. A. P. T. Easson and F. L. Pyman, J. Chem. Soc. (C), 1931, 2991 Search PubMed.
  11. S. E. S. Ebrahimi, M. C. Bibby, K. R. Fox and K. T. Douglas, Anti-Cancer Drug Des., 1995, 10, 463 Search PubMed.
  12. J. A. Parkinson, J. Barber, K. T. Douglas, J. Rosamund and D. Sharples, Biochemistry, 1990, 29, 10 181 CrossRef CAS.
  13. F. G. Loontiens, L. W. McLaughlin, S. Diekmann and R. M. Clegg, Biochemistry, 1991, 30, 182 CrossRef CAS.
  14. M. S. Searle and K. J. Embrey, Nucleic Acids Res., 1990, 18, 3753 CAS.
  15. J. A. Parkinson, S. E. Ebrahimi, J. H. McKie and K. T. Douglas, Biochemistry, 1994, 33, 8442 CrossRef CAS.
  16. M. Teng, N. Usman, C. A. Frederick and A. H. Wang, Nucleic Acids Res., 1988, 16, 2671 CAS.
  17. J. R. Quintana, A. A. Lipanov and R. E. Dickerson, Biochemistry, 1991, 30, 10 294 CrossRef CAS.
Click here to see how this site uses Cookies. View our privacy policy here.