Trimethylsilyl chloride-accelerated reduction and pinacol coupling of carbonyl compounds by means of samarium diiodide

Abstract

The combination of samarium diiodide (SmI₂) and trimethylsilyl chloride (Me₃SiCl) in THF–HMPA is found to accelerate the reduction of sterically hindered and enolisable ketones, and also to accelerate pinacolisation of the carbonyl compounds depending on the reaction conditions.

References

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