Reversibility of S-nitrosothiol formation

Abstract

The nitrosation of thiols is sufficiently reversible to allow, in many cases, the low thiol concentration present at equilibrium to reduce Cu²⁺ and bring about loss of nitric oxide from S-nitrosothiols.

References

1. A. P. Dicks, H. R. Swift, D. L. H. Williams, A. R. Butler, H. H. Al-Sadoni and B. G. Cox, J. Chem. Soc., Perkin Trans. 2, 1996, 481.
2. A. P. Dicks and D. L. H. Williams, Chem. Biol., 1996, 3, 655.
3. E. J. Langford, A. S. Brown, R. J. Wainwright, A. J. de Belder, M. R. Thomas, R. E. A. Smith, M. W. Radomski, J. F. Martin and S. Moncada, Lancet, 1994, 344, 1458.
4. L. Jia, C. Bonaventura, J. Bonaventura and J. S. Stamler, Nature, 1996, 380, 221.
5. P. Herves and D. L. H. Williams, to be published.
6. D. L. H. Williams, Nitrosation, 1988, Cambridge University Press, p. 150.
7. J. Casado, F. M. Lorenzo, M. Mosquera and M. F. R. Prieto, Can. J. Chem., 1984, 62, 136.
8. S. E. Aldred, D. L. H. Williams and M. Garley, J. Chem. Soc., Perkin Trans. 2, 1982, 777.
9. L. R. Dix and D. L. H. Williams, J. Chem. Soc., Perkin Trans. 2, 1984, 109.
10. P. W. Riddles, R. L. Blakeley and B. Zerner, Anal. Biochem., 1979, 94, 75.
11. A. C. F. Gorren, A. Schrammel, K. Schmidt and B. Mayer, Arch. Biochem. Biophys., 1996, 330, 219.