Kinetics of nitric oxide scavenging by ruthenium(iii) polyaminocarboxylates: novel therapeutic agents for septic shock

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Nathan A. Davies, Mike T. Wilson, Elizabeth Slade, Simon P. Fricker, Barry A. Murrer, Nigel A. Powell and Graham R. Henderson


Abstract

The reaction of two representative ruthenium(III) polyaminocarboxylates with nitric oxide are rapid (k > 107M-1 s-1 at pH 7.4 and 7.3 °C) forming tight (K = 108M-1) ruthenium(II) mononitrosyls.


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