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DOI: 10.1039/A606275J (Paper) Reference Section for: Chem. Commun., 1997, 27-28

Recognition of platinum(ii) amine complexes by nucleotides: role ofphosphate and carbonyl groups in ([15N3]diethylenetriamine)-(guanosine 5′-monophosphate)platinum(ii)

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Zijian Guo, Peter J. Sadler and Erle Zang

Abstract

Two-dimensional [1H,15N] NMR studies show that in the model monofunctional DNA adduct [Pt([15N3]dien)(5′-GMP-N7 )]2+ [5′-GMP = guanosine 5′-monophosphate, dien = 1,5-diamino-3-azapentane (prepared by a novel synthesis from glycine)], stereospecific hydrogen-bonding interactions involving Pt–NH protons are promoted by deprotonation of both the 5′-phosphate group and N1H of coordinated 5′-GMP.

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