DOI: 10.1039/A605800K
(Paper)
Reference Section for: Chem. Commun., 1997, 43-44
Nanogram-scale derivatization of hydroxy groups for highly sensitive HPLC/MS/CD detection
(Note: The full text of this document is currently only available in the PDF Version )
Ning Zhao, Jin-Song Guo, Lee-Chiang Lo, Nina Berova, Koji Nakanishi, Garner T. Haupert, M. Warrack and Adrienne A. Tymiak
Abstract
A strategy for performing submicrogram-scale structural studies of saponins and related compounds is worked out by: (i) naphthoylation to sensitize HPLC detection by fluorescence as well as configurational studies by exciton coupled CD; and (ii) ω-cyanoundecanoylation to increase LC/MS sensitivity (ca. 100-fold).
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