Determination of Aluminium-26 in Biological Materials by Accelerator Mass Spectrometry

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S. J. King, C. Oldham, J. F. Popplewell, R. S. Carling, J. P. Day, S. J. King, L. K. Fifield, R. G. Cresswell, Kexin Liu and M. L. di Tada


Abstract

Studies of the biological chemistry of aluminium can gain significantly from the use of the long-lived isotope 26Al as a tracer, although the cost of the isotope often precludes its determination by radiochemical counting techniques. Accelerator mass spectrometry (AMS) provides an ultra-sensitive method of determination, free from isobaric interference from atomic (26Mg) or molecular species. The source materials for AMS can be aluminium oxide or phosphate, both of which can be readily prepared at a sufficient level of purity from biological substrates. Natural aluminium (27Al, 100%) is added to the preparations as a chemical yield monitor and to provide the reference for the isotope ratio measurement. 26Al/27Al ratios can be determined over the range 1014–107, implying a limit of detection for 26Al of around 1018 g. The precision of measurement and long-term reproducibility are <5% and <7% (RSD), respectively. Chemical methodologies for routine measurements on blood and urine samples have been developed.


References

  1. T. P. Flaten, A. C. Alfrey, J. D. Birchall, J. Savory and R. A. Yokel, J. Toxicol. Environ. Health, 1996, 48, 527 CrossRef CAS.
  2. A. E. Litherland, Philos. Trans. R. Soc. London, Ser A, 1987, 323, 5 Search PubMed.
  3. J. P. Day, J. Barker, S. J. King, R. V. Miller, J. Templar, J. S. Lilley, P. V. Drumm, G. W. A. Newton, L. K. Fifield, J. O. H. Stone, G. L. Allan, J. A. Edwardson, P. B. Moore, I. N. Ferrier, N. D. Priest, D. Newton, R. J. Talbot, J. H. Brock, L. Sanchez, C. B. Dobson, R. F. Itzhaki, A. Radunovic and M. W. B. Bradbury, Nucl. Instrum. Methods Phys. Res., Sect. B, 1994, 92, 463 CrossRef CAS.
  4. L. K. Fifield, T. R. Ophel, J. R. Bird, G. E. Calf, G. B. Allison and A. R. Chivas, Nucl. Instrum. Methods Phys. Res., Sect. B, 1987, 29, 114 CrossRef.
  5. R. C. Reedy, C. Tuniz and D. Fink, Nucl. Instrum. Methods Phys. Res., Section B, 1994, 92, 335 Search PubMed.
  6. R. E. M. Hedges, Nucl. Instrum. Methods Phys. Res., Sect. B, 1990, 52, 428 CrossRef.
  7. J. S. Vogel and K. W. Turtletaub, Nucl. Instrum. Methods Phys. Res., Sect. B, 1994, 92, 445 CrossRef CAS.
  8. D. Elmore, M. H. Bhattacharyya, N. Sacco-Gibson and D. P. Peterson, Nucl. Instrum. Methods Phys. Res., Sect. B, 1990, 52, 531 CrossRef.
  9. J. Barker, J. P. Day, T. W. Aitken, T. R. Charlesworth, R. C. Cunningham, P. V. Drumm, J. S. Lilley, G. W. A. Newton and M. J. Smithson, Nucl. Instrum. Methods Phys. Res., Sect. B, 1990, 52, 540 CrossRef.
  10. J. P. Day, J. Barker, L. J. A. Evans, J. Perks and P. J. Seabright, Lancet, 1991, 337, 1345 CrossRef CAS.
  11. S. J. King, J. P. Day, P. B. Moore, J. A. Edwardson, G. A. Taylor, L. K. Fifield and R. G. Cresswell, Nucl. Instrum. Methods Phys. Res., Ser. B, 1997, 123, 254 Search PubMed.
  12. N. D. Priest, D. Newton, J. P. Day, R. J. Talbot and A. J. Warner, Hum. Exp. Toxicol., 1995, 14, 287 Search PubMed.
  13. N. D. Priest, R. J. Talbot, J. G. Austin, J. P. Day, S. J. King, L. K. Fifield and R. G. Cresswell, Biometals, 1996, 9, 221 CrossRef CAS.
  14. L. K. Fifield, R. G. Cresswell, M. L. di Tada, T. R. Ophel, J. P. Day, A. P. Clacher, S. J. King and N. D. Priest, Nucl. Instrum. Methods Phys. Res., Sect. B, 1996, 117, 295 CrossRef CAS.
  15. L. K. Fifield, A. P. Clacher, K. Morris, S. J. King, R. G. Cresswell, J. P. Day and F. R. Livens, Nucl. Instrum. Methods Phys. Res., Ser. B, 1997, 123, 400 Search PubMed.
  16. L. K. Fifield, G. L. Allan, J. O. H. Stone and T. R. Ophel, Nucl. Instrum. Methods Phys. Res., Sect. B, 1994, 92, 85 CrossRef CAS.
  17. L. K. Fifield, T. R. Ophel, G. L. Allan, J. R. Bird and R. F. Davie, Nucl. Instrum. Methods Phys. Res., Sect. B, 1990, 52, 233 CrossRef.
  18. K. Brand, Nucl. Instrum. Methods Phys. Res., 1977, 141, 519 Search PubMed.
  19. R. Middleton, Nucl. Instrum. Methods Phys. Res., 1984, 220, 105 Search PubMed.
  20. A. Vogel, A Textbook of Quantitative Inorganic Analysis, Longmans, London, 1978, 3rd edn., p. 516 Search PubMed.
  21. H. C. Eshelman, J. A. Dean, O. Menis and T. C. Rains, Anal. Chem., 1959, 31, 183 CrossRef CAS.
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