Derivatization of Amphetamine and Methamphetamine With 1,2-Naphthoquinone 4-Sulfonic Acid Into Solid-phase Extraction Cartridges. Determination of Amphetamine in Pharmaceutical and Urine Samples

Abstract

The derivatization of amphetamine and methamphetamine with 1,2-naphthoquinone-4-sulfonate (NQS) into solid-phase extraction cartridges (C₁₈) is described. Optimum conditions were the use of carbonate–hydrogencarbonate buffer of pH 10, a 10 min reaction time at 25 °C and an NQS concentration of 9.6 × 10^-3M. The accuracy and the precision of the method were tested. The results obtained with the proposed liquid–solid procedure were compared with those obtained with a traditional liquid–liquid extraction with hexane–ethyl acetate. The procedure was used to measure amphetamine in pharmaceutical and urine samples

References

1. P. Campíns Falcó, A. Sevillano Cabeza and C. Molins Legua, J. Liq. Chromatogr., 1994, 17, 731.
2. B. Kinberger, J. Chromatogr., 1981, 213, 166.
3. M. Endo, H. Imamichi, M. Moriyasu and Y. Hasmimoto, J. Chromatogr., 1980, 196, 334.
4. K. Hayakawa, K. Hasegawa, K. Imaizumi, O. S. Wong and M. Miyazaki, J. Chromatogr., 1989, 464, 343.
5. C. X. Gao, T. Y. Chou and I. S. Krull, Anal. Chem., 1989, 61, 1538.
6. F. X. Zhou, I. S. Krull and B. Feibush, J. Chromatogr., 1992, 609, 103.
7. A. J. Bourque and I. R. Krull, J. Chromatogr., 1991, 537, 123.
8. S. Suzuki, T. Inoue and T. Niwaguchi, J. Chromatogr., 1983, 267, 381.
9. B. M. Farrell and T. M. Jefferies, J. Chromatogr., 1983, 272, 111.
10. Pharmaceutical Society of Britian, Clarke's Isolation and Identification of Drugs, Pharmceutical Press, London, 1986, pp. 349 and 763.
11. C. Molins Legua, P. Campíns Falcó and A. Sevillano Cabeza, Anal. Chim. Acta, 1993, 283, 635.
12. C. Molins Legua, P. Campíns Falcó and A. Sevillano Cabeza, Fresenius' J. Anal. Chem., 1994, 349, 311.
13. A. Sevillano Cabeza, P. Campíns Falcó and C. Molins Legua, Anal. Letters, 1994, 27, 1095.
14. P. Campíns Falcó, F. Bosch Reig, A. Sevillano Cabeza and C. Molins Legua, Anal. Chim. Acta., 1994, 287, 41.
15. P. Campíns Falcó, C. Molins Legua, R. Herraez Hernández and A. Sevillano Cabeza, J. Chromatogr. B, 1995, 663, 235.
16. P. Campíns Falcó, A. Sevillano Cabeza, C. Molins Legua and M. Kohlmann, J. Chromatogr. B, 1996, 687, 239.
17. R. Herráez Hernández, P. Campíns Falcó and A. Sevillano Cabeza, Anal. Chem., 1996, 68, 734.
18. ACS Committee on Environmental Improvement, Anal. Chem., 1980, 52, 2242.
19. IUPAC, ‘Compendium of Analytical Nomenclature’, Pergamon Press, Oxford, 1978.
20. W. J. Youden, Anal. Chem., 1947, 19, 946.