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DOI: 10.1039/A700137A (Paper) Reference Section for: Analyst, 1997, 122, 491-494

Potentiometric and Coulometric Titration of 6-Propyl-2-Thiouracil

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Witold Ciesielski and Robert Zakrzewski

Abstract

A method for the determination of 6-propyl-2-thiouracil involving its reaction with iodine in an alkaline medium is presented. In volumetric titration with potentiometric end-point detection, the range of determination is 125–500 µmol (21–85 mg). In coulometric titration using biamperometric end-point detection, 0.5–5.0 µmol (0.085–0.85 mg) of 6-propyl-2-thiouracil was successfully determined. The RSD in all applied techniques was <1%. The methods developed were applied to the determination of 6-propyl-2-thiouracil in tablets.

References

  1. W. Orłowski and W. Hartwing, Nauka o Chorobach, PZWL, Warsaw, 1992, vol. 3, pp. 81–82 Search PubMed.
  2. D. J. Hurst, The Chemistry and Biochemistry of Pyrimidines, Purines and Pteridines, Wiley, New York, 1980 Search PubMed.
  3. M. Kucharski, H. Sikorska-Tomicka and T. Szumiło, Zesz. Nauk. Politech. Białostock., 1981, 7, 31 Search PubMed.
  4. A. Berggren and W. Kirsten, Farm. Revy, 1951, 16, 254 Search PubMed.
  5. K. J. Nikolić, B. S. Stankowić and M. R. Bogovac, J. Serb. Chem. Soc., 1994, 59, 385 Search PubMed.
  6. S. Pinzauti, G. Popeschi and E. La Porta, J. Pharm. Biomed. Anal., 1983, 1, 47 CrossRef CAS.
  7. S. Pinzauti, V. Dal Piaz and E. La Porta, J. Pharm. Sci., 1973, 62, 997 CAS.
  8. C. F. Abbott, J. Pharm. Pharmacol., 1953, 5, 53 Search PubMed.
  9. H. Wojahn and E. Wempe, Pharm. Zentralhalle, 1953, 92, 124 Search PubMed.
  10. H. Wojahn and E. Wempe, Arch. Pharm. (Weinheim, Ger.), 1953, 286, 344 Search PubMed.
  11. H. Wojahn, Pharm. Acta Helv., 1953, 28, 336 CAS.
  12. H. Wojahn and E. Wempe, Arch. Pharm. (Weinheim, Ger.), 1952, 285, 280 Search PubMed.
  13. K. Backe-Hansen, Medd. Norsk. Farm. Selskap., 1955, 17, 63 Search PubMed; Chem. Abstr., 1956, 50, 113c Search PubMed.
  14. H. N. Christensen, J. Biol. Chem., 1946, 162, 27 CAS.
  15. F. S. Hom, S. A. Veresh and J. J. Miskel, J. Assoc. Off. Anal. Chem., 1971, 54, 1420 Search PubMed.
  16. E. Guler, Eczacilik Bul., 1982, 24(1), 14 Search PubMed; Chem. Abstr., 1982, 96, 205509b Search PubMed.
  17. A. Besada, N. B. Tadros and Y. A. Gawargious, Egypt. J. Pharm. Sci., 1989, 30(1–4), 251 Search PubMed; Chem. Abstr., 1990, 112, 12006a Search PubMed.
  18. Ch. R. Ratlift, P. F. Gilliland and F. F. Hall, Clin. Chem., 1972, 18, 1373.
  19. J. von Brüggemann and J. Schole, Landwirtsch. Forsch., 1967, 21, 134 Search PubMed.
  20. W. Doden and R. Kopf, Arch. Exp. Pathol. Pharmakol., 1951, 213, 51 Search PubMed; Chem. Abstr., 1952, 46, 383d Search PubMed.
  21. M. E. Mohamed, M. S. Towakhol and H. Y. Absoul-Enein, Chem. Biomed. Environ. Instrum., 1981, 11, 241 Search PubMed; Chem. Abstr., 1981, 95, 175878f Search PubMed.
  22. B. H. Berg, Acta Pharm. Suec., 1971, 8, 453 Search PubMed.
  23. R. A. McAllister and K. W. Howellst, J. Pharm. Pharmacol., 1952, 4, 259 Search PubMed.
  24. S. Bruno, Boll. Chim. Farm., 1963, 102, 478 Search PubMed.
  25. W. L. Holt and L. N. Mattson, Anal. Chem., 1949, 21, 1389 CrossRef CAS.
  26. J. M. Lopez, P. C. Gonzalez and P. Sanz Pedrero, An. R. Acad. Farm., 1981, 47(2), 161 Search PubMed; Chem. Abstr., 1981, 95, 175874b Search PubMed.
  27. J. Kurzawa, Chem. Anal. (Warsaw), 1987, 32, 875 Search PubMed.
  28. J. Kurzawa, Zesz. Nauk. Politechn. Poznańsk., 1986, 16, 41 Search PubMed.
  29. J. Kurzawa, Quim. Anal., 1985, 4, 117 Search PubMed.
  30. W. Jędrzejewski and W. Ciesielski, Chem. Anal. (Warsaw), 1978, 23, 781 Search PubMed.
  31. W. Ciesielski, Chem. Anal. (Warsaw), 1991, 36, 555 Search PubMed.
  32. British Pharmacopeia Commission, British Pharmacopoeia 1988, H. M. Stationery Office, London, 1988, pp. 475 and 996 Search PubMed.
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