Infrared Discrimination of Enantiomerically Enriched and Racemic Samples of Methamphetamine Salts

(Note: The full text of this document is currently only available in the PDF Version )

J. S. Chappell


Abstract

A relatively rapid and simple means of enantiomer determination is described for the determination of methamphetamine, a common drug of abuse. The method employs the well known technique of infrared transmission spectrometry on solid samples dispersed within an alkali metal halide matrix. This approach exploits the solid-state, ion-exchange reaction between methamphetamine hydrochloride and a potassium iodide matrix and the subsequent formation of the hydriodide salt in situ. The infrared properties of the hydriodide salt are distinct for enantiomerically enriched and racemic samples, and therefore are readily distinguished by infrared transmission spectrometry. This technique uses materials and instrumentation that are generally available to most crime laboratories. The applicability of this method to some other amine drugs is discussed.


References

  1. Proposed 1995 Guideline Amendments, 60 Federal Register 25074 Search PubMed.
  2. A. Allen and T. S. Cantrell, Forensic Sci. Int., 1989, 42, 183 CrossRef CAS.
  3. Official Methods of Analysis of the Association of Official Analytical Chemists, ed. Horwitz, W., Association of Official Analysis Chemists, Arlington, VA, 10th edn., 1965, p. 597 Search PubMed.
  4. T. C. Kram and I. S. Lurie, Forensic Sci. Int., 1992, 55, 131 CrossRef.
  5. M. J. LaBelle, C. Savard, B. A. Dawson, D. B. Black, L. K. Katyal, F. Zrcek and A. W. By, Forensic Sci. Int., 1995, 71, 215 CrossRef.
  6. C. E. Wells, J. Ass. Off. Anal. Chem., 1970, 53, 113 Search PubMed.
  7. F. T. Noggle and C. R. Clark, J. Forensic Sci., 1986, 31, 732 Search PubMed.
  8. Y. Makino, S. Ohta and M. Hirobe, Forensic Sci. Int., 1996, 78, 65 CrossRef CAS.
  9. I. S. Lurie, J. Chromatogr., 1992, 605, 269 CrossRef CAS.
  10. I. Lurie, R. Klein, T. Dal Cason, M. LaBelle, R. Brenneisen and R. Weinberger, Anal. Chem., 1994, 66, 4019 CrossRef CAS.
  11. A. Allen and D. Cooper, Microgram, 1979, 12, 24 Search PubMed.
  12. R. L. Shriner, R. C. Fuson and D. Y. Curtin, The Systematic Identification of Organic Compounds, Wiley, New York, 1964, pp. 256–259 Search PubMed.
  13. J. Jacques, A. Collet and S. H. Wilen, Enantiomers, Racemates, and Resolutions, Krieger, Malabar, FL, 1994, pp. 43–48 Search PubMed.
  14. J. S. Chappell, Forensic Sci. Int., 1995, 75, 1 CrossRef CAS.
  15. R. A. Ely, Drug Enforcement Administration, San Francisco, CA, USA, personal communication, 1993.
  16. N. B. Colthup, L. H. Daly and S. E. Wiberly, Introduction to Infrared and Raman Spectroscopy, Academic Press, New York, 1964, pp. 281–282 Search PubMed.
  17. J. A. Heagy, Drug Enforcement Administration, San Francisco, CA, USA, personal communication, 1996.
  18. J. A. Heagy, Anal. Chem., 1970, 42, 1459 CrossRef CAS.
  19. For review, see L. Pauling, The Nature of the Chemical Bond, Cornell University Press, Ithaca, NY, 3rd edn., 1960, pp. 449–504 Search PubMed.
  20. B. Chenon and C. Sandorfy, Can. J. Chem., 1958, 36, 1181 CAS.
  21. C. Brissette and C. Sandorfy, Can. J. Chem., 1960, 38, 34 CAS.
Click here to see how this site uses Cookies. View our privacy policy here.