DOI: 10.1039/A705884E
(Paper)
Reference Section for: Anal. Commun., 1997, 34, 303-306
Preliminary Evaluation of a Molecular Imprinted Polymer for Solid-phase Extraction of Tamoxifen
(Note: The full text of this document is currently only available in the PDF Version )
B. A. Rashid, R. J. Briggs, J. N. Hay and D. Stevenson
Abstract
A molecular imprinted polymer, prepared around a tamoxifen template, has been synthesised. The feasibility of using this polymer for solid-phase extraction of tamoxifen from biological samples has been investigated. The results show that the drug can be quantitatively retained and eluted from the polymer using acetonitrile–acetic acid. Experiments with biological fluids indicate that clean traces are obtained for HPLC with UV detection using this type of protocol.
References
- S. J. Shahtaheri, M. F. Katmeh, P. Kwasowski and D. Stevenson, J. Chromatogr. A, 1995, 697, 131 CrossRef CAS.
- A. Martin-Esteban, P. Kwasowski and D. Stevenson, Chromatographia, 1997, 45, 368.
- B. Rashid, P. Kwasowski and D. Stevenson, in Biofluid Assay for Peptide-Related and Other Drugs, ed. Reid, E., Hill, H. E. and Wilson, I. D., Royal Society of Chemistry, Cambridge, 1996, pp. 219–223 Search PubMed.
- B. A. Rashid, P. Kwasowski and D. Stevenson, Pharm. Sci., 1996, 2, 115 CAS.
- G. Wulff, Angew. Chem., Int. Engl., 1995, 34, 1812 CrossRef CAS.
- K. Mosbach and O. Ramstrom, Bio/Technology, 1996, 14, 163 Search PubMed.
- P. Martin, I. D. Wilson, D. E. Morgan, G. R. Jones and K. Jones, Anal. Commun., 1997, 34, 45 RSC.
- L. I. Andersson, A. Paprica and T. Arvidsson, Chromatographia, 1977, 46, 57.
- M. T. Muldoon and L. H. Stanker, Anal. Chem., 1997, 69, 803 CrossRef CAS.
- J. Matsui, M. Okada, M. Tsuruoka and T. Takeuchi, Anal. Commun., 1997, 34, 85 RSC.
- L. I. Andersson, R. Muller, G. Vlatakis and K. Mosbach, Proc. Natl. Acad. Sci. USA, 1995, 92, 47-88-4792.