DOI: 10.1039/A701515A
(Paper)
Reference Section for: Anal. Commun., 1997, 34, 153-154
Amperometric Drug Response of a DNA Membrane Electrode Based on the Enzyme-mimic Catalytic Activity of a DNA–Copper(II) Complex
(Note: The full text of this document is currently only available in the PDF Version )
Yasushi Hasebe, Koji Hamada, Takuya Hirano and Shunichi Uchiyama
Abstract
The catalytic activity of a DNA–CuII complex for the oxidation of aminoethanethiol is reversibly inhibited by intercalation with the DNA-binding drug quinacrine, in a concentration dependent manner,which could be detected via an amperometric signal by using a DNA–CuII complex entrapping hydrogel and an oxygen electrode.
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