Separation of the Enantiomers of Propranolol by Incorporation of Molecularly Imprinted Polymer Particles as Chiral Selectors in Capillary Electrophoresis

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Michaela Walshe, Edelmiro Garcia, Joshua Howarth, Malcolm R. Smyth and Mary T. Kelly


Abstract

A molecularly imprinted polymer (MIP) was prepared to S-propranolol using N-acryloyl–alanine. The R- and S-enantiomers of propranolol were successfully separated by capillary electrophoresis, using the MIP particles prepared from N-acryloyl–alanine as a chiral mobile phase additive.


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