Tandem synthesis of polypropionate chains–highly stereoselective synthesis of the ansa chain of streptovaricin U and protostreptovaricins based on stereospecific methylation of γ,δ-epoxy acrylates by trimethylaluminium
Abstract
The highly stereoselective synthesis of the ansa chain segment 23 of streptovaricin U and protostreptovaricins (I and II) is achieved by stereospecific methylation of γ,δ-epoxy acrylates with trimethylaluminium.