Comparison of 3′,5′- and 2′,5′-linked DNA duplex stabilities by electrospray ionization mass spectrometry

Abstract

Two mutually complementary strands of 2′,5′-linked DNA form a unique noncovalent complex observed by electrospray ionization mass spectrometry; by the latter method, the double-stranded state of a 2′,5′-linked DNA duplex is less stable than the natural DNA duplex of identical base composition.