Issue 4, 1996

Synthesis of a novel GC-specific covalent-binding DNA affinity-cleavage agent based on pyrrolobenzodiazepines (PBDs)

Abstract

A novel GC-selective pyrrolobenzodiazepine–EDTA conjugate is synthesized that covalently binds to DNA at 5′-PuGPu sequences leading to site-specific cleavage.

Article information

Article type
Paper

Chem. Commun., 1996, 563-565

Synthesis of a novel GC-specific covalent-binding DNA affinity-cleavage agent based on pyrrolobenzodiazepines (PBDs)

D. E. Thurston, S. J. Morris and J. A. Hartley, Chem. Commun., 1996, 563 DOI: 10.1039/CC9960000563

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