5,9-Methanobenzoannulenamines. Part 1. Improved synthesis of 11-amino-5,9-methanobenzo[8]annulenes
Abstract
Reaction of 1-(3,4-dihydronapthalen-2-yl)pyrrolidine with acrylaldehyde gave an epimeric mixture of 8-hydroxy-5,6,7,8,9,10-hexahydro-5,9-methanobenzo[8]annulen-11-ones which was used for the synthesis of several 11 -amino derivatives.