Issue 23, 1995
From the journal:

Journal of the Chemical Society, Chemical Communications

Substitution of the methyl groups with ethyl groups at C-10 and C-15 of 2,3-oxidosqualene halts the enzymatic reaction of oxidosqualene–lanosterol cyclase at the monocyclic ring stage

Tsutomu Hoshino,   Eiichi Ishibashi  and  Kimiyoshi Kaneko  

Abstract

Incubation of the substrate analogue, (3S)-(E,E,E,E,E)-10,15-diethyl-2,6,19,23-tetramethyl-2,3-epoxytetracosa-6,10,14,18,22-pentaene (–)-1, with 2,3-oxidosqualene–lanosterol cyclase from pigs liver gave unprecedented cyclization products 2 and 3 having a monocyclic skeleton.

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Article information

DOI
https://doi.org/10.1039/C39950002401
Article type
Paper

J. Chem. Soc., Chem. Commun., 1995, 2401-2402

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Substitution of the methyl groups with ethyl groups at C-10 and C-15 of 2,3-oxidosqualene halts the enzymatic reaction of oxidosqualene–lanosterol cyclase at the monocyclic ring stage

T. Hoshino, E. Ishibashi and K. Kaneko, J. Chem. Soc., Chem. Commun., 1995, 2401 DOI: 10.1039/C39950002401

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