Diastereoisomerically pure dinucleosidylphosphorofluoridites and their application in stereospecific synthesis of dinucleosidylphosphorofluoridothionates
Abstract
Dinucleosidylphosphorofluoridites with dA(Bz), dC(Bz) or dT at the 3′-end and dT at the 5′-end are synthesised, separated into their diastereoisomers and shown to be converted stereospecifically into the corresponding phosphorofluoridothionates high hydrolytic stability.